帝國製薬株式会社

1848	Shozo Akazawa, the 5th head of the family, obtains a certificate granting him permission from the government to deal in medicines, and starts business	Governmental certificate giving permission to deal in medicines
1883	Chutaro Akazawa obtains a license to operate a pharmacy	‘Honzo-zufu’, a botanical encyclopedia from the time of Akazawa-Yakkan (trade name)
1892	Permission to sell “rodent repellant” obtained, marking the beginning of the business in the field
1918	“Teikoku Seiyaku Co., Ltd.” established with capital of 1 million yen	Plant at the time of establishment
1926	“Chemical Cat”, yellow phosphorous-based rodent poison, launched	Drugs, circa 1920	Caps and bags of company peddlers, circa 1925
1938	“Horxis®”, a prototype of the current medicated plaster, launched
1943	A group of 212 companies in Kagawa Prefecture join together to establish “Kagawa Prefecture Pharmaceutical Co., Ltd”. and Chutaro Akazawa is appointed as the first president
1953	Osaka Plant established in Higashi-yodogawa-ku (now Yodogawa-ku), Osaka
1957	Osaka Plant spun off as “Fuso Chemical Co., Ltd.” and Shozo Akazawa is appointed president
1974	Teikoku Seiyaku’s medicated plasters approved for prescription use, becoming the company’s main product line
1975	First stage of new production plant for plasters (former Plant No.1) completed Final stage of construction completed in 1978	Products manufactured, 1975
1984	Nine-story pharmaceutical development laboratory (now Administration Bldg.) completed at the site of headquarters complex	Development laboratory
1985	“Teikoku Kampo Seiyaku Co., Ltd”. established New Shirotori Plant completed in Shirotori-cho (now Minato, Higashikagawa), Kagawa Prefecture
1986	Teikoku Seiyaku acquires stock in Ohta Pharmaceutical Co., Ltd. and starts participating in management
1988	“Catlep®”, Japan’s first transdermal indomethacin plaster for prescription use, approved and production begins New plant (now Plant No.2), 5 stories and 6,451 square meters, completed at the site of headquarters complex	Catlep	New plant at time of completion (Now Plant No.2)
1989	Distribution Center completed in Shirotori-cho (now Minato, Higashikagawa), Kagawa Prefecture	Shirotori Distribution Center
1991	Company contributed to the Department of Pharmaco-Bio-Informatics, established at Kagawa Medical University (now Faculty of Medicine, Kagawa University)
1992	Sales division spun off as an independent company, “Teikoku Medix Co., Ltd.”
1993	Construction of Plant No.4 dedicated to manufacture of tapes and ointment completed Ikeda Plant dedicated to manufacture of rodent poison begins operations in Ikeda-cho (now Miyoshi), Tokushima Prefecture (Transferred to Ikeda Yakusou Co., Ltd.) “Seltouch®”, a transdermal felbinac plaster for prescription use, approved and production begins
1994	Production begins at Tokushima Plant (Teikoku Kampo Seiyaku Co., Ltd.)	Tokushima Plant
1995	Non-prescription drug division (OTC) spun off as an independent company, “Teikoku Pharmacare Co., Ltd.” Teikoku Seiyaku joins the Japan Pharmaceutical Manufacturers Association
1997	Site of the former Sanbonmatsu Plant of Toyobo Co., Ltd., adjacent to Teikoku Seiyaku headquarters, acquired US subsidiary, “Teikoku Pharma USA, Inc.”, established Land adjacent to Tokushima Plant acquired and Donari Plant dedicated to manufacture of cosmetics and related products begins operations
1998	150th anniversary of the founding of the business and 80th anniversary of the establishment of the company celebrated “Sogyo 150-Nen Shi” (History of the First 150 Years) published	Symbol of the 150th Anniversary
1999	“Lidoderm®”, the analgesic plaster for the treatment of post-herpetic neuralgia, approved and launched in the US
2000	“Dovonex® ointment” for the treatment of psoriasis vulgaris approved and launched(Transferred to LEO Pharma K.K. in 2014) Construction of Plant No.8 completed at the site of former Toyobo Co., Ltd. and production begins
2001	A morphine sulfate sustained-release capsule approved and production begins Production begins at new Plant No.7
2003	“Fuso Teiyaku Qingdao Co., Ltd.”, established as a joint company by Teikoku Seiyaku Co., Ltd., Fuso Chemical Co., Ltd. and Qingdao Fuso Refining & Processing Co., Ltd. New pharmacology building completed
2004	Teikoku Pharma USA, Inc. moves into a new building with a new manufacturing plant	Teikoku Pharma USA, Inc.
2006	Formulation research building completed at the site of Sanbonmatsu Plant “Omneed® Ketoprofen Patch”, the first OTC ketoprofen patch in Japan, launched by Teikoku Pharmacare Co., Ltd. Tokyo Office moves into Teikoku’s own building in Nihonbashi-honcho
2007	Teikoku Seiyaku Memorial Gallery, Akazawa Memorial Gallery and Guest House "FUTAGOJIMA" completed	Teikoku Seiyaku Memorial Gallery	Guest House"FUTAGOJIMA"
2008	160th anniversary of the founding of the business and 90th anniversary of the establishment of the company celebrated Teikoku Medix Co., Ltd. sold
2009	Construction of a new warehouse completed next to the Tokushima warehouse
2010	“Seltouch® Tape 70”, a felbinac tape for prescription use, approved and marketing begins in 2011 “Catlep® Tape 70mg” and “Catlep® Tape 35mg”, indomethacin tapes for prescription use, approved and marketing begins
2011	Capital reduced to 100 million yen
2012	A methadone hydrochloride tablet, approved and marketing begins in 2013
2013	A fentanyl citrate buccal tablet co-developed with Taiho Pharmaceutical Co.,Ltd., approved and marketing begins A oxycodone hydrochloride sustained-release capsule approved and marketing begins in 2014
2014	Established Drug & Medical Device Sales Division to sell medicinal products and started to sell Catlep, Inteban, Drenison of Sumitomo Dainippon Pharma based on the distribution right Completion of Plant No. 9
2015	Tokyo Office moved to Ogura Building located in Nihonbashi-kobunacho
2016	Opened Higashi-Nihon Logistics Center in Higashi-Nihon MDC of Hitachi Logistics
2017	Awarded a Medal of Honor(the Medal with Dark Blue Ribbon) Completion of Plant No. 10 to manufacture ointment and cream Launch RUPAFIN® 10 mg upon NDA approval
2018	Celebrated the one hundred and seventieth anniversary since foundation of the company and the one hundredth anniversary since incorporation	Symbol of the 170th Anniversary
2019	Seren Pharmaceuticals, Inc. becomes an affiliated company of Teikoku Seiyaku
2020	Teikoku Seiyaku makes the Japanese Ministry of Economy, Trade and Industry’s 2020 Global Niche Top Companies Selection 100 List Receives Eruboshi certification. Eruboshi is awarded by the Ministry of Health, Labour and Welfare to employers who promote the participation and advancement of women in the workplace
2022	Acquired manufacturing and marketing approval for Japan’s first Donepezil transdermal therapeutic system. ALLYDONE® 27.5 mg patches and ALLYDONE® 55 mg patches go on the market the following year
2023	Achieves Kurumin mark certification as a childcare supportive organization

HISTORY