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shikaku space November 22, 2017
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Launch of Rupafin® tablets in Japan
Allergy treatment agent with new mechanism of action shows strong effectiveness with dual action (anti-PAF and antihistamine action)
Teikoku Seiyaku Co., Ltd. (Head Office: Higashikagawa City, Kagawa; President and CEO: Misako Fujioka) and Mitsubishi Tanabe Pharma Corporation (Head Office: Osaka City; President and Representative Director: Masayuki Mitsuka) have announced today that the both companies would launch Rupafin® tablets (generic name: rupatadine fumarate) in Japan on November 27, 2017, following today’s inclusion of Rupafin® in the National Health Insurance drug price list.
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This oral allergy treatment agent has a new mechanism of action. In addition to antihistamine action, Rupafin® tablets also have anti-PAF (platelet activating factor) action. Histamine is widely known as a chemical mediator that brings about allergic reactions. PAF induces vasodilation, vascular permeability enhancement, vascular nerve stimulation, and white blood cell activation. As a result, it brings about such symptoms as sneezing, runny nose, and nasal congestion, and it is closely involved in the pathology of allergic disorders. Rupafin® tablets control these two chemical mediators and show strong dual action (anti-PAF and antihistamine), thereby controlling the symptoms of allergic disorders.
This drug was discovered by J. Uriach Y COMPANIA, S.A., of Spain, and had been approved in more than 80 countries around the world as of November 2017. Overseas, it has indications of allergic rhinitis and urticaria and is administered orally at a dosage of 10mg once a day. In Japan, in May 2014 Teikoku Seiyaku concluded a development and sales licensing agreement with J. Uriach Y COMPANIA, and Teikoku Seiyaku has advanced development on its own.
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In October 2016, Teikoku Seiyaku and Mitsubishi Tanabe Pharma reached a basic agreement for sales of Rupafin® tablets. Teikoku Seiyaku will supply the product to Mitsubishi Tanabe Pharma, which will distribute and market it. In addition, the two companies will jointly implement information provision activities for medical institutions.
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For further information, please contact:
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Teikoku Seiyaku Co., Ltd., General Affairs Department
Tel: +81-3-3661-3331
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Mitsubishi Tanabe Pharma Corporation Corporate Communications Department
Tel:+81-6-6205-5211
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